Actualización de la colección de tipos del herbario MACB, II

CARRASCO, M. A. & MARTÍN-BLANCO, C. J. 2002. Actualización de la colección de Tipos del Herbario MACB. Bot. Complutensis, 26: 59-62. Se actualiza la Colección de Tipos del Herbario MACB, presentando los Typus de siete nombres. Señalamos la categoria de cada Tipo y los herbarios que tienen material tipo de los mismos taxones. Los nuevos Tipos son: 2 Holotypus, 4 Isotypus, 1 Isolectotypus y 2 Sintypus.CARRASCO, M. A. & MARTÍN-BLANCO, C. J. 2002. Update of the MACB type collection, II. Bot. Complutensis, 26: 59-62. In this paper the Type collection of the MACB Herbarium is update. We indicate the category of seven names (Holotypus, Isotypus Isolectotypus or Sintypus), as well as the herbariums with other type specimens of the same taxa. The new Typus are: 2 Holotypus, 4 Isotypus, 1 Isolectotypus and 2 Sintypus

Seis plantas de interés para el conocimiento de la flora de Ciudad Real (España)

Presentamos en este trabajo noticia sobre seis plantas vasculares interesantes para el conocimiento florístico de la provincia de Ciudad Real. Son primeras citas provinciales: Cosentinia vellea (Aiton) Tod., Cuscuta planiflora Ten., Cytinus ruber Fourr. eQuintanar, A.; Martín-Blanco, C. J. & Carrasco, M. A. 2004. Six interesting plants for the floristic knowledge of flora in Ciudad Real (Spain). Bot. Complut. 28: 75-77. Here we introduce six interesting vascular plants for the knowledge of flora in Ciudad Real. They are first provincial samples: Cosentinia vellea (Aiton) Tod., Cuscuta planiflora Ten., Cytinus ruber Fourr. ex Fritsch., Lotus hispidus Desf. ex DC. and Ononis varelae Devesa, the last mentioned it is in Toledo as well for the first time. Orobanche ramosa L. subsp. nana (Reut.) Cout. is mentioned for the second time in Ciudad Real. The samples of Ciudad Real have been collected in San Lorenzo de Calatrava, at the extern border of Valle de Alcudia. The sheets that testify this records are kept in the herbarium MACB

Tuning interfacial domain walls in GdCo/Gd/GdCo′ spring magnets

Under the terms of the Creative Commons Attribution License 3.0 (CC-BY).-- et al.Spring magnets based on GdCo multilayers have been prepared to study the nucleation and evolution of interfacial domain walls (iDWs) depending on layer composition and interlayer coupling. GdCo alloy compositions in each layer were chosen so that their net magnetization aligns either with the Gd (Gd35Co65) or Co(Gd11Co89) sublattices. This condition forces an antiparallel arrangement of the layers' net magnetization and leads to nucleation of iDWs above critical magnetic fields whose values are dictated by the interplay between Zeeman and exchange energies. By combining x-ray resonant magnetic scattering with Kerr magnetometry, we provide detailed insight into the nucleation and spatial profile of the iDWs. For strong coupling (GdCo/GdCo′ bilayer), iDWs are centered at the interface but with asymmetric width depending on each layer magnetization. When interlayer coupling is weakened by introducing a thin Gd interlayer, the exchange spring effect becomes restricted to a lower temperature and field range than observed in the bilayer structure. Due to the ferromagnetic alignment between the high magnetization Gd35Co65 layer and the Gd interlayer, the iDW shrinks and moves into the lower exchange Gd interlayer, causing a reduction of iDW energy.Work supported by Spanish Ministerio de Economía y Competitividad (MINECO) under grant FIS2013-45469 and Spanish Ministerio de Ciencia e Innovacion (MICINN) under grant FIS2008-06249. Work at Argonne was supported by the U.S. Department of Energy, Office of Science, under Contract No. DE-AC02-06CH11357.Peer Reviewe

Cerámicas prerromanas del castillo de Aroche (Huelva)

Se estudia en este trabajo un conjunto cerámico de época prerromana registrado en las excavaciones del castillo medieval de Aroche (Huelva)._________________________In this work are presented the preroman pottery registered in the archaeological excavation made in the medieval castle of Aroche (Huelva, SW Spain), near to Reina's Gate

Control of magnetic domain wall motion in Co microwires by tridimensional e-beam lithographied structures

Resumen del póster presentado al 6th Spanish Workshop in Nanolithography celebrado en Zaragoza (España) del 28 al 30 de octubre de 2014.Work supported by the Spanish MICINN FIS2008-06249 and CSIC JAE Predoc grants.Peer Reviewe

Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm

Marfan syndrome (MFS) is an autosomal dominant disorder of the connective tissue caused by mutations in the FBN1 (fibrillin-1) gene encoding a large glycoprotein in the extracellular matrix called fibrillin-1. The major complication of this connective disorder is the risk to develop thoracic aortic aneurysm. To date, no effective pharmacologic therapies have been identified for the management of thoracic aortic disease and the only options capable of preventing aneurysm rupture are endovascular repair or open surgery. Here, we have studied the role of mitochondrial dysfunction in the progression of thoracic aortic aneurysm and mitochondrial boosting strategies as a potential treatment to managing aortic aneurysms.Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III (PI16/188, PI19/855), the European Regional D evelopment Fund, and the European Commission through H2020-EU.1.1, European Research Council grant ERC-2016-StG 715322-EndoMitTalk, and Gobierno de Espana SAF2016-80305P. This work was partially supported by Comunidad de Madrid (S2017/BMD 3867 RENIM-CM) and cofinanced by the European Structural and Investment Fund. M.M. is supported by the Miguel Servet Program (CP 19/014, Fundacion de Investigacion del Hospital 12 de Octubr

Abnormalities in gray matter volume in patients with borderline personality disorder and their relation to lifetime depression: A VBM study

Background Structural imaging studies of borderline personality disorder (BPD) have found regions of reduced cortical volume, but these have varied considerably across studies. Reduced hippocampus and amygdala volume have also been a regular finding in studies using conventional volumetric measurement. How far comorbid major depression, which is common in BPD and can also affect in brain structure, influences the findings is not clear. Methods Seventy-six women with BPD and 76 matched controls were examined using whole-brain voxel-based morphometry (VBM). The hippocampus and amygdala were also measured, using both conventional volume measurement and VBM within a mask restricted to these two subcortical structures. Lifetime history of major depression was assessed using structured psychiatric interview. Results At a threshold of p = 0.05 corrected, the BPD patients showed clusters of volume reduction in the dorsolateral prefrontal cortex bilaterally and in the pregenual/subgenual medial frontal cortex. There was no evidence of volume reductions in the hippocampus or amygdala, either on conventional volumetry or using VBM masked to these regions. Instead there was evidence of right-sided enlargement of these structures. No significant structural differences were found between patients with and without lifetime major depression. Conclusions According to this study, BPD is characterized by a restricted pattern of cortical volume reduction involving the dorsolateral frontal cortex and the medial frontal cortex, both areas of potential relevance for the clinical features of the disorder. Previous findings concerning reduced hippocampus and amygdala volume in the disorder are not supported. Brain structural findings in BPD do not appear to be explainable on the basis of history of associated lifetime major depression

The biological age linked to oxidative stress modifies breast cancer aggressiveness

The incidence of breast cancer increases with age until menopause, and breast cancer is more aggressive in younger women. The existence of epidemiological links between breast cancer and aging indicates that both processes share some common mechanisms of development. Oxidative stress is associated with both cancer susceptibility and aging. Here we observed that ERBB2-positive breast cancer, which developed in genetically heterogeneous ERBB2-positive transgenic mice generated by a backcross, is more aggressive in chronologically younger than in older mice (differentiated by the median survival of the cohort that was 79 weeks), similar to what occurs in humans. In this cohort, we estimated the oxidative biological age using a mathematical model that integrated several subphenotypes directly or indirectly related to oxidative stress. The model selected the serum levels of HDL-cholesterol and magnesium and total AKT1 and glutathione concentrations in the liver. The grade of aging was calculated as the difference between the predicted biological age and the chronological age. This comparison permitted the identification of biologically younger and older mice compared with their chronological age. Interestingly, biologically older mice developed more aggressive breast cancer than the biologically younger mice. Genomic regions on chromosomes 2 and 15 linked to the grade of oxidative aging were identified. The levels of expression of Zbp1 located on chromosome 2, a gene related to necroptosis and inflammation, positively correlated with the grade of aging and tumour aggressiveness. Moreover, the pattern of gene expression of genes linked to the inflammation and the response to infection pathways was enriched in the livers of biologically old mice. This study shows part of the complex interactions between breast cancer and aging.JPL was partially supported by FEDER and the MICINN (SAF2014-56989-R and SAF2017-88854R), the Instituto de Salud Carlos III (PIE14/00066), >Proyectos Integrados IBSAL 2015> (IBY15/00003), the Sandra Ibarra Foundation >de Solidaridad Frente al Cáncer> Foundation and >We can be heroes> Foundation. JHM was supported by the National Institutes of Health, a National Cancer Institute grant (R01 CA116481), and the Low-Dose Scientific Focus Area, Office of Biological & Environmental Research, US Department of Energy (DE-AC02-05CH11231).Peer Reviewe

Lack of Association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid Arthritis

Introduction. Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. Recent studies have identified the ABO rs579459, PPAP2B rs17114036, and ADAMTS7 rs3825807 polymorphisms as genetic variants associated with coronary artery disease and the PIK3CG rs17398575 and EDNRA rs1878406 polymorphisms as the most significant signals related to the presence of carotid plaque in nonrheumatic Caucasian individuals. Accordingly, we evaluated the potential relationship between these 5 polymorphisms and subclinical atherosclerosis (assessed by carotid intima-media thickness (cIMT) and presence/absence of carotid plaques) and CV disease in RA. Material and Methods. 2140 Spanish RA patients were genotyped for the 5 polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 620 of these patients by carotid ultrasonography technology. Results. No statistically significant differences were found when each polymorphism was assessed according to cIMT values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV disease after adjusting for potential confounders. Conclusion. Our results do not confirm association between ABO rs579459, PPAP2B rs17114036, ADAMTS7 rs3825807, PIK3CG rs17398575, and EDNRA rs1878406 and subclinical atherosclerosis and CV disease in RA.European Union FEDER Funds and “Fondo de Investigación Sanitaria” (Grants PI06/0024, PS09/00748, and PI12/00060) from “Instituto de Salud Carlos III” (ISCIII, Health Ministry, Spain). It was also partially supported by RETICS Programs RD12/0009/0013 and RD12/0009/0004 (RIER) from “Instituto de Salud Carlos III” (ISCIII, Health Ministry, Spain) and in part by grants from the European IMI BTCure Program.Peer reviewe

Lack of association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritis

Introduction. Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. Recent studies have identified the ABO rs579459, PPAP2B rs17114036, and ADAMTS7 rs3825807 polymorphisms as genetic variants associated with coronary artery disease and the PIK3CG rs17398575 and EDNRA rs1878406 polymorphisms as the most significant signals related to the presence of carotid plaque in nonrheumatic Caucasian individuals. Accordingly, we evaluated the potential relationship between these 5 polymorphisms and subclinical atherosclerosis (assessed by carotid intima-media thickness (cIMT) and presence/absence of carotid plaques) and CV disease in RA. Material and Methods. 2140 Spanish RA patients were genotyped for the 5 polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 620 of these patients by carotid ultrasonography technology. Results. No statistically significant differences were found when each polymorphism was assessed according to cIMT values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV disease after adjusting for potential confounders. Conclusion. Our results do not confirm association between ABO rs579459, PPAP2B rs17114036, ADAMTS7 rs3825807, PIK3CG rs17398575, and EDNRA rs1878406 and subclinical atherosclerosis and CV disease in RA